Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

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Year of Establishment
2016-05-25
  • Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
  • Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
  • Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
  • Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
  • Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
  • Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
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  • Overview
  • Product Description
Overview

Basic Info.

Application
Face
Material
Hyaluronic Acid
Model No.
Proluma
Shelf Life
2years
Function
Remove Wrinkle, Skin Tightening
Transport Package
Cartons or Foam Box
Specification
365 mg x 1 vial (5 ml)
Trademark
Proluma
Origin
Korea

Product Description

Product Description

Product Information

Proluma PLA by Genese Labs France, a cutting-edge natural collagen stimulator designed to rejuvenate skin texture gradually. Unlike traditional PLA fillers, Proluma boasts a unique formulation with perfect spherical shapes and uniform particle size, requiring lower injection power. This innovative product utilizes Genese Labs's exclusive freeze-drying technique, significantly reducing treatment time by allowing for quicker dissolution. Crafted with biodegradable materials, Proluma ensures no residue is left in the body over time, offering a safe,
efficient, and groundbreaking solution for skin rejuvenation.

  • Even volume creation through spherical PLA particles.
  • High safety due to the use of biocompatible and eco-friendly material.
  • Reduce treatment time due to faster filler dissolution.
  • Soft injection due to uniform particle size and long-lasting power due to heavier molecular weight of more than 200,000DA.

Efficiency

1.NEW TISSUES AND COLLAGEN PRODUCTION : Proluma effectively promotes the generation of new tissues and collagen, demonstrating a progressive cellular response to the treatment :

  • By Week 2 post-injection, cellular proliferation is evident as cells begin to adhere to the surface of PDLLA particles and occupy the interstitial spaces between them, effectively filling these voids with new tissue growth.
  • By Week 8, the previously observed spaces between PDLLA particles no longer exist, having been completely occupied by cells. These cells initiate migration into the porous structure of the PDLLA particles, as indicated by the yellow arrow.
  • By Weeks 12 and 20, an advanced stage of cellular integration is observed. Cells have penetrated deeply into the inner regions of the PDLLA particles, thoroughly inhabiting both the internal spaces and the areas between particles, culminating in significant tissue regeneration and volumization.

 

2.LONG LASTING EFFECT : Proluma stands out by not only correcting wrinkles and folds but also ensuring lasting volumization across facial areas, offering a durable alternative to traditional fillers that target specific folds. Its effectiveness in enhancing natural facial volume through the stimulation of new collagen and tissue production contributes to its long-lasting results.

3.SAFETY : PDLLA, known for its safety and non-toxic properties, undergoes degradation in the body via hydrolysis, breaking down into lactic acid and glycogen. Through metabolic processes, PDLLA is further decomposed into carbon dioxide and water, which are then safely excreted from the body. PDLLA is recognized for its safety, having received approval from the US FDA and classified under its GRAS (Generally Recognized as Safe) designation since 1984.

 

How To Use:

Thirty minutes before the procedure, prepare a 9cc suspension by combining 7cc of Sterile Water For Injection (SWFI) and 2cc  with the contents of the Proluma vial.

  1. Remove cap and clean : Remove the flip-off cap and sanitize the penetrable vial stopper using an antiseptic
  2. Mix with Sterile Water For Injection(SWFI) : Connect an 18G needle to a sterile, single-use 7-mL syringe and draw 7 mL of Sterile Water For Injection (SWFI) into the syringe. Invert the vial, insert the needle through the stopper, and gradually inject the SWFI into the vial.
  3. Agitate the vial upright prior to injection : Vigorously shake the vial by hand or use a single vial swirling agitator for approximately 1 minute to dissolve the excipients. Examine the vial for any undissolved lumps and, if necessary, continue shaking until they are dissolved.
  4. Mix with Sterile Water For Injection(SWFI) : Immediately before treatment, cleanse the rubber cap of Proluma. Introduce 2cc  and then fill with the diluted solution using an 18G needle. It is important not to store the solution within the syringe for an extended period.
  5. Withdrawing the suspension : Sanitize the stopper of the vial, then use an 18G single-use, sterile syringe, either 1 or 3-mL, to withdraw the suspension.
  6. Switching to a 25G or 26G needle : Before proceeding with the injection, replace the needle with a sterile 25G or 26G needle.

 

Application Areas: Inject into the deep dermis layer, where this method actively stimulates collagen production more effectively than conventional fillers

  • Primary Target : Dry, thin skin with fine wrinkles
  • Secondary Target : Nasolabial folds
Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

SYNERFILL is the specially compounded PLLA+H-HA+L-HA collagen stimulating and lifting filler that 

stimulates collagen inside of skin to induce collagenesis and improves wrinkles and restore facial volume 

losses.

Also helps reduction of wrinkle depth, smoothing of skin texture and improves skin hydration, skin compliance

& skin elasticity. 

 

Indication: 
- Stimulation and generation of collagen under the skin

- Reducing fine wrinkles

- Smoothing of skin texture

- Improves skin hydration, skin compliance, skin elasticity

- Volume replenishment

 

Why SYNERFILL?

- Long lasting

- Evenly restores volume & improves deep wrinkles

- Quick procedure and effect

- No residues left in the body

- FDA Proven Safety

 

Treatment Area:

- Nasolabial folds, Temple, Cheek, Jowls, Eye, Chin, Jawline, Marionette lines, Forehead, Neck

 

Treatment:

- 2 Treatments / month (1 month interval)

 

Duration:

- 24 months

 

Volume:

- 260 mg / vial / box

Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

RAVELLO - PLLA 200mg
L-HA 30mg/ml & H-HA 30mg/ml

RAVELLO PLLA 200mg is a medical device for treating severe facial wrinkles and folds, replacing volume defects and improving facial contour deformities. 

As a safe and effective collagen stimulator & regenerator, RAVELLO PLLA  helps to restore natural volume for ageing skin-loss collagen. It increases the skin's elasticity and volume naturally and makes looking young. Depending on the condition of the patients, 2 or 3 times of treatment are recommended for the longevity of volume staying)

 

Indication: For treatment of severe facial wrinkles, folds, and replacement of facial contour deformities

     The result of the procedure lasts up to 24 months. 
    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler


    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

    Layer/Effect: Wrinkle improvement to Subcutaneous, dermal layer.

    Particle Distribution (Average): Average 30pm.

    Proprietary technology that can mass - produce microspheres of uniform size from nano to micro.

    FILLICIA 200 PLA + HA

    Main ingredients: Poly (D, L-lactic acid), (PLA).

    Dosage & volume: 200mg / vial (box), 150mg PLA + 50mg HA.

    Layer/Effect: Wrinkle improvement to Subcutaneous, dermal layer.

     

    Particle Distribution (Average): Average 30pm.

    FILLICIA 1000 PLA + HA

     

    Main ingredients: Poly (D, L-lactic acid), (PLA).

    Dosage & volume: 1000mg / vial(box), 750mg PLA + 250mg HA.

    Layer/Effect: Wrinkle improvement to Subcutaneous, dermal layer.

    Particle Distribution (Average): Average 30pm.

     

    What is Microsphere?

    Small spherical fine particle. It is a key ingredient of 4th generation filler as collagen stimulator in body.

    In the case of HA fillers have a simple filling effect, but powder fillers induce skin tissue regeneration to remove wrinkles naturally.

    What is a biodegradable substance?
    • Hydrolyzed in body and used as major ingredient in cosmetics, tissue engineering device and depot formula.

    • There are various types as PLLA, PDO and PCL used for a long time and they have various physical properties depending on composition and molecule size.

    High Precision: Production of perfect spherical microparticles; Produce desired uniform particles.

    Solid Strength: Stable spherical shape during processing; Stable and constant biodegradation in the body.

    Control the Duration: Control duration by polymer type & property; Expandable with uniform size.

    Excellent Safety: Dissolving thread ingredients that have been used for a long time; Complete loss of absorption in body after tissue regeneration

    Produce high-quality microspheres: Unique platform technology that can mass - produce spherical particles of uniform size

    Control of degradation period in body: Production of microspheres with different degradation periods in body through precise control

    Wide range of possibilities: Widely applicable to pharmaceuticals, medical devices and cosmetics

    Spherical Microparticles
    • Particle size can be freely adjusted according processing size of the membrane

    • Uniform production with various materials such as PLA, PCL, and PLGA

    Porous microparticles
    • Production of fine particles with many pores on the surface

    • Faster collagen stimulation and biodegradation

    Effect

    Continuously promotes tissue proliferation in the skin during the year. Effective in treatment of scars, stretch marks (striae), keloid scars.

    • Improving skin turgor, removes fine wrinkles, moisturizes, return lost volumes, long lasting lifting effect, scars removal, pores tightening.

    • Stimulated tissues regenerate sub-materials such as elastin, collagen, and amino-peptides, and eventually form new tissue.

    • Some volume loss occurs during 1-2 weeks after injection. The production of cell and collagen restores lost volume at week 3-4 after injection.

    Possible correction areas: Face; Forehead; Neck; Body; Buttocks.

    Features

    • Easily injectable, Biocompatible.

    • Fully biodegrades from human body up to 24 months.

    • Spherical shapes 50-60 micron in size.

    • Should be mixed with liquid diluent before the procedure.

    No. of treatments

    • 3 times, 1 procedure/month

    Dose

    • 1 to 5 vials per procedure.

    • Face, forehead, nasolabial folds, marionette lines, cheeks - 2.5-5ml

    • Neck and decolette- 1.5-3ml

    • Body 2.5-10ml

    Injection Technique: Fanning technique

    Shelf period after opening: Must be used immediately after dilution; No re-use.

    Application: Cannula 23-25G, SubQ

    Long-lasting effect: Up to 24 months

    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

     

     

    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
     
    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
     
    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler
    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal FillerKorea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

    Korea Proluma PLA by Genese Labs France, a Cutting-Edge Natural Collagen Stimulator Designed to Rejuvenate Skin Texture Gradually Dermal Filler

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